Accession	MF_00046
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00046; [distribution of match scores in UniProtKB];[seed alignment for MF_00046]

Identifier

MURC

Protein name

RecName: Full=UDP-N-acetylmuramate--L-alanine ligase; EC=6.3.2.8; AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase;

Gene name

murC

FUNCTION: Cell wall formation (By similarity).

CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (Probable).

SIMILARITY: Belongs to the murCDEF family.

Pfam	PF01225; Mur_ligase; 1; PF02875; Mur_ligase_C; 1;
TIGRFAMs	TIGR01082; murC; 1;

ATP-binding, Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Cytoplasm, Ligase, Nucleotide-binding, Peptidoglycan synthesis.

GO:0005524; Molecular function: ATP binding.
GO:0008763; Molecular function: UDP-N-acetylmuramate-L-alanine ligase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: MURC_ECOLI (P17952)
Key		From		To		Description		Condition		FTGroup
NP_BIND		126		132		ATP (Potential)		G-x(2)-G-K-[ST]-[STG]

Size range:	431-539 amino acids
Related UniRules:	MF_00208 (MURE)
Template:	P17952 (MURC_ECOLI); Q9WY73 (MURC_THEMA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: MF_00047 (ddl)
Duplicate:	None
Plasmid encoded:	None
Comments:	Weird insertion in ANASP and SYNY3. Probable wrong start in LACLA.