Accession	MF_00042
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 23)

Data class

Protein

Predictors

HAMAP; MF_00042; [distribution of match scores in UniProtKB];[seed alignment for MF_00042]

Identifier

RNH

Protein name

RecName: Full=Ribonuclease H; Short=RNase H; EC=3.1.26.4;

Gene name

rnhA

FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).

CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-phosphomonoester.

COFACTOR: Binds 1 magnesium ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding (By similarity).

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the RNase H family.

SIMILARITY: Contains 1 RNase H domain.

Pfam	PF00075; rnaseH; 1;
PROSITE	PS50879; RNASE_H; 1; trigger=PRU00408;

Cytoplasm, Hydrolase, Nuclease, Endonuclease, Magnesium, Metal-binding.

GO:0000287; Molecular function: magnesium ion binding.
GO:0004523; Molecular function: ribonuclease H activity.
GO:0006401; Biological process: RNA catabolic process.
GO:0005737; Cellular component: cytoplasm.

From: RNH_ECOLI (P0A7Y4)
Key		From		To		Description		Condition		FTGroup
METAL		10		10		Magnesium 1 (By similarity)		D
METAL		10		10		Magnesium 2 (By similarity)		D
METAL		48		48		Magnesium 1 (By similarity)		E
METAL		70		70		Magnesium 1 (By similarity)		D
METAL		134		134		Magnesium 2 (By similarity)		D

Size range:	143-231 amino acids
Related UniRules:	None
Template:	P0A7Y4 (RNH_ECOLI); P29253 (RNH_THET8): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Possible C-terminal domain in STRCO. Divergence in TREPA.