Accession	MF_00038
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 38)

Data class

Protein

Predictors

HAMAP; MF_00038; [distribution of match scores in UniProtKB];[seed alignment for MF_00038]

Identifier

MRAY

Protein name

RecName: Full=Phospho-N-acetylmuramoyl-pentapeptide-transferase; EC=2.7.8.13; AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;

Gene name

mraY

Protein name

RecName: Full=Putative phospho-N-acetylmuramoyl-pentapeptide-transferase; EC=2.7.8.13; AltName: Full=UDP-MurNAc-pentapeptide phosphotransferase;

FUNCTION: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity).

CATALYTIC ACTIVITY: UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the glycosyltransferase 4 family. MraY subfamily.

Pfam	PF00953; Glycos_transf_4; 1;
TIGRFAMs	TIGR00445; mraY; 1;
PROSITE	PS01347; MRAY_1; 1; PS01348; MRAY_2; 1;
General	Transmembrane; -; 8-11; trigger=Yes;

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis.

Cell inner membrane.

Cell membrane, Membrane, Transferase, Transmembrane.

GO:0008963; Molecular function: phospho-N-acetylmuramoyl-pentapeptide-transferase activity.

GO:0009252; Biological process: peptidoglycan biosynthetic process.

GO:0005886; Cellular component: plasma membrane.

Size range:	302-422 amino acids
Related UniRules:	None
Template:	P0A6W3 (MRAY_ECOLI); Q2FZ93 (MRAY_STAA8): [Recover all]

Scope:

Bacteria

Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Very divergent TREPA