Accession	MF_00037
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00037; [distribution of match scores in UniProtKB];[seed alignment for MF_00037]

Identifier

MURB

Protein name

RecName: Full=UDP-N-acetylenolpyruvoylglucosamine reductase; EC=1.1.1.158; AltName: Full=UDP-N-acetylmuramate dehydrogenase;

Gene name

murB

FUNCTION: Cell wall formation (By similarity).

CATALYTIC ACTIVITY: UDP-N-acetylmuramate + NADP(+) = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH.

COFACTOR: FAD (By similarity).

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (Probable).

SIMILARITY: Belongs to the murB family.

PROSITE	PS51387; FAD_PCMH; 1;
Pfam	PF01565; FAD_binding_4; 1; PF02873; MurB_C; 1;
TIGRFAMs	TIGR00179; murB; 1;

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Cytoplasm, FAD, Flavoprotein, NADP, Oxidoreductase, Peptidoglycan synthesis.

GO:0008762; Molecular function: UDP-N-acetylmuramate dehydrogenase activity.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: MURB_ECOLI (P08373)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		159		159		By similarity		R
ACT_SITE		229		229		Proton donor (By similarity)		[CS]
ACT_SITE		325		325		By similarity		E

Size range:	258-383 amino acids
Related UniRules:	None
Template:	P18579 (MURB_BACSU); P08373 (MURB_ECOLI); P61431 (MURB_STAAU): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAN, BACCR, CORGL
Plasmid encoded:	None
Comments:	Possible wrong start in ANASP and SYNY3. Divergent sequences in BIFLO and TREPA.