Accession	MF_00036
Dates	1-JUN-2001 (Created) 25-SEP-2008 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_00036_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00036_B]

Predictors

HAMAP; MF_00036_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00036_A]

Identifier

SYA

Protein name

RecName: Full=Alanyl-tRNA synthetase; EC=6.1.1.7; AltName: Full=Alanine--tRNA ligase; Short=AlaRS;

Gene name

alaS

CATALYTIC ACTIVITY: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.

Pfam	PF01411; tRNA-synt_2c; 1;
PRINTS	PR00980; TRNASYNTHALA; 1;
TIGRFAMs	TIGR00344; alaS; 1;
PROSITE	PS50860; AA_TRNA_LIGASE_II_ALA; 1;

Acetylation.

Cytoplasm, Aminoacyl-tRNA synthetase, Protein biosynthesis, Ligase, ATP-binding, Nucleotide-binding.

Metal-binding, Zinc, Zinc-finger.

GO:0004813; Molecular function: alanine-tRNA ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006419; Biological process: alanyl-tRNA aminoacylation.

GO:0008270; Molecular function: zinc ion binding.

GO:0005737; Cellular component: cytoplasm.

From: SYA_ECOLI (P00957)
Key		From		To		Description		Condition		FTGroup
ZN_FING (Optional)		179		192		C2H2-type		C-x(2)-C-x(6)-H-x(2)-H

Key		From		To		Description		Condition		FTGroup
MOD_RES		74		74		N6-acetyllysine (By similarity)		K

Size range:

593-966 amino acids

Size range:

870-932 amino acids

Related UniRules:	None
Template:	P00957 (SYA_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in CLOPH
Plasmid encoded:	None
Comments:	Bad alignment with BURBU, BORGA, BORAP, BORHD, TREDE, TREPA and second copy of CLOPH (shorter sequences).