Accession	MF_00033
Dates	1-JUN-2001 (Created) 26-SEP-2008 (Last updated, Version 38)

Data class

Protein

Predictors

HAMAP; MF_00033; [distribution of match scores in UniProtKB];[seed alignment for MF_00033]

Identifier

MURG

Protein name

RecName: Full=UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; EC=2.4.1.227; AltName: Full=Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase;

Gene name

murG

FUNCTION: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) (By similarity).

CATALYTIC ACTIVITY: UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.

PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.

SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (By similarity).

SIMILARITY: Belongs to the glycosyltransferase 28 family. MurG subfamily.

Pfam	PF04101; Glyco_tran_28_C; 1; PF03033; Glyco_transf_28; 1;
TIGRFAMs	TIGR01133; murG; 1;

Cell cycle, Cell division, Cell membrane, Cell shape, Cell wall biogenesis/degradation, Glycosyltransferase.

Cell inner membrane.

Membrane, Peptidoglycan synthesis, Transferase.

GO:0050511; Molecular function: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity.
GO:0030259; Biological process: lipid glycosylation.
GO:0009252; Biological process: peptidoglycan biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Size range:	333-441 amino acids
Related UniRules:	None
Template:	P17443 (MURG_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACAH, BACAN, BACC1, BACCR, BACCZ, BACHK
Plasmid encoded:	None