Accession	MF_00022
Dates	1-JUN-2001 (Created) 3-MAR-2009 (Last updated, Version 30)

Data class

Protein

Predictors

HAMAP; MF_00022_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00022_B]

Predictors

HAMAP; MF_00022_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00022_A]

Identifier

SYE

Protein name

RecName: Full=Glutamyl-tRNA synthetase; EC=6.1.1.17; AltName: Full=Glutamate--tRNA ligase; Short=GluRS;

Gene name

gltX

FUNCTION: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity).

CATALYTIC ACTIVITY: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

COFACTOR: Binds 1 zinc ion per subunit (By similarity).

SUBUNIT: Monomer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.

Pfam	PF00749; tRNA-synt_1c; 1;

Pfam	PF03950; tRNA-synt_1c_C; 1;

PRINTS	PR00987; TRNASYNTHGLU; 1;
TIGRFAMs	TIGR00463; gltX_arch; 1; TIGR00464; gltX_bact; 1;
PROSITE	PS00178; AA_TRNA_LIGASE_I; 1;

Aminoacyl-tRNA synthetase, ATP-binding, Cytoplasm, Ligase, Nucleotide-binding, Protein biosynthesis.

Metal-binding, Zinc.

GO:0005524; Molecular function: ATP binding.
GO:0004818; Molecular function: glutamate-tRNA ligase activity.

GO:0008270; Molecular function: zinc ion binding.

GO:0006424; Biological process: glutamyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

From: SYE_ECOLI (P04805)
Key		From		To		Description		Condition		FTGroup
MOTIF		9		19		"HIGH" region		P-[SN]-P-x(4)-[HR]-[LIVMAT]-[GE]-x
MOTIF		237		241		"KMSKS" region		x-[LIMSF]-S-K-[KR]
METAL (Optional)		98		98		Zinc (By similarity)		C		1
METAL (Optional)		100		100		Zinc (By similarity)		C		1
METAL (Optional)		125		125		Zinc (By similarity)		[CH]		1
METAL (Optional)		127		127		Zinc (By similarity)		[HED]		1
BINDING		240		240		ATP (By similarity)		K

From: SYE_METJA (Q58772)
Key		From		To		Description		Condition		FTGroup
MOTIF		98		108		"HIGH" region		P-[SNE]-P-x(4)-[HTS]-[LIVM]-G-x

Size range:

431-546 amino acids

Size range:

548-588 amino acids

Related UniRules:	MF_01428 (GLUQ)
Template:	P04805 (SYE_ECOLI); O25360 (SYE2_HELPY); P27000 (SYE_THET8); Q8DLI5 (SYE_THEEB): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: <Unknown>
Duplicate:	in ACIBL, ACICJ, ACIF5, ALHEH, ANAMM, ANAPZ, ARCB4, BARBK, BARHE, BARQU, BART1, BEII9, BRUA1, BRUA2, BRUAB, BRUC2, BRUME, BRUO2, BRUSI, BRUSU, CALS8, CAMC1, CAMC5, CAMFF, CAMHC, CAMJ8, CAMJD, CAMJE, CAMJJ, CAMJR, COXB1, COXB2, COXBN, COXBR, COXBU, DINSH, EHRCJ, EHRCR, EHRRG, EHRRW, ERYLH, FERNB, GLUDA, GLUOX, GRABC, HALHL, HELAH, HELHP, HELP2, HELPG, HELPH, HELPJ, HELPS, HELPY, HYPNA, JANSC, LACBA, MAGMM, MARMM, MESSB, METCA, METEP, METPB, METRJ, METS4, NEOSM, NITOC, NITSB, NOVAD, OCHA4, ORITB, ORITI, PARDP, PARL1, PETMO, RHILO, RHOCS, RHORT, RHOS1, RHOS4, RHOS5, RICAH, RICB8, RICBR, RICCK, RICCN, RICFE, RICM5, RICPR, RICRO, RICRS, RICTY, ROSDO, RUBXD, SILPO, SILST, SPHAL, SPHWW, SULDN, SULNB, SYNAS, SYNWW, THELT, THEM4, THEMA, THEP1, THEP3, THEPX, THESQ, THETN, WOLPM, WOLPP, WOLSU, WOLTR, XANP2, ZYMMO
Plasmid encoded:	None