Accession	MF_00012
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 26)

Data class

Protein

Predictors

HAMAP; MF_00012; [distribution of match scores in UniProtKB];[seed alignment for MF_00012]

Identifier

ILVD

Protein name

RecName: Full=Dihydroxy-acid dehydratase; Short=DAD; EC=4.2.1.9;

Gene name

ilvD

CATALYTIC ACTIVITY: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O.

COFACTOR: Binds 1 4Fe-4S cluster (Potential).

PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.

PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.

SIMILARITY: Belongs to the ilvD/edd family.

Pfam	PF00920; ILVD_EDD; 1;
TIGRFAMs	TIGR00110; ilvD; 1;
PROSITE	PS00886; ILVD_EDD_1; 1; PS00887; ILVD_EDD_2; 1;

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Lyase, Metal-binding, Iron, Iron-sulfur, 4Fe-4S.

GO:0004160; Molecular function: dihydroxy-acid dehydratase activity.
GO:0009097; Biological process: isoleucine biosynthetic process.
GO:0009099; Biological process: valine biosynthetic process.

From: ILVD_ECOLI (P05791)
Key		From		To		Description		Condition		FTGroup
METAL		122		122		Iron-sulfur (4Fe-4S) (Potential)		C
METAL		195		195		Iron-sulfur (4Fe-4S) (Potential)		C

Size range:	547-629 amino acids
Related UniRules:	None
Template:	P05791 (ILVD_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BORBR, BORPA, BORPE, BRAJA, COREF, RHILO
Plasmid encoded:	None