Accession	MF_00008
Dates	1-JUN-2001 (Created) 6-FEB-2009 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_00008; [distribution of match scores in UniProtKB];[seed alignment for MF_00008]

Identifier

TYSY

Protein name

RecName: Full=Thymidylate synthase; Short=TS; Short=TSase; EC=2.1.1.45;

Gene name

thyA

FUNCTION: Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.

SUBUNIT: Homodimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the thymidylate synthase family. Bacterial-type thyA subfamily.

PROSITE	PS00091; THYMIDYLATE_SYNTHASE; 1;
Pfam	PF00303; Thymidylat_synt; 1;
PRINTS	PR00108; THYMDSNTHASE; 1;
TIGRFAMs	TIGR03284; thym_sym; 1;

Cytoplasm, Methyltransferase, Nucleotide biosynthesis, Transferase.

GO:0004799; Molecular function: thymidylate synthase activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: TYSY_ECOLI (P0A884)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		146		146		By similarity		C

Size range:	258-323 amino acids
Related UniRules:	MF_01686 (TYSY (supersedes the current rule))
Template:	P42326 (TYSY1_BACSU); P0A884 (TYSY_ECOLI); P00469 (TYSY_LACCA): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in BACSU, BACAM, STAEQ
Plasmid encoded:	in STAAU
Comments:	Duplicates in BACSU or BACAM are due to the presence of a phage-derived TS See: MEDLINE; 98311083. Tam N.H., Borriss R.; "Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families."; Mol. Gen. Genet. 258:427-430(1998). Archaeal thyA belong to a separate family (MF_01686)