Accession	MF_00008
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00008_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00008_B]

Predictors

HAMAP; MF_00008_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00008_A]

Identifier

TYSY

Protein name

RecName: Full=Thymidylate synthase; Short=TS; Short=TSase; EC=2.1.1.45;

Gene name

thyA

FUNCTION: Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

SUBUNIT: Homodimer (By similarity).

SUBUNIT: Monomer (By similarity).

PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the thymidylate synthase family.

Pfam	PF00303; thymidylat_synt; 1;
PROSITE	PS00091; THYMIDYLATE_SYNTHASE; 1;

Cytoplasm, Transferase, Methyltransferase, Nucleotide biosynthesis.

GO:0004799; Molecular function: thymidylate synthase activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: TYSY_ECOLI (P0A884)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		146		146		By similarity		C

From: TYSY_METTM (P80305)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		146		146		By similarity		C

Size range:

221-323 amino acids

Size range:

209-223 amino acids

Related UniRules:	None
Template:	P42326 (TYSA_BACSU); P0A884 (TYSY_ECOLI); P00469 (TYSY_LACCA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BACSU, STAEQ
Plasmid encoded:	in STAAU
Comments:	Duplicates in BACSU or BACLI are due to the presence of a phage-derived TS See: MEDLINE; 98311083. Tam N.H., Borriss R.; "Genes encoding thymidylate synthases A and B in the genus Bacillus are members of two distinct families."; Mol. Gen. Genet. 258:427-430(1998).