Accession	MF_00001
Dates	1-JUN-2001 (Created) 7-JUN-2008 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00001; [distribution of match scores in UniProtKB];[seed alignment for MF_00001]

Identifier

PYRB

Protein name

RecName: Full=Aspartate carbamoyltransferase; EC=2.1.3.2; AltName: Full=Aspartate transcarbamylase; Short=ATCase;

Gene name

pyrB

CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.

PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6.

SUBUNIT: Heterooligomer of catalytic and regulatory chains (By similarity).

SIMILARITY: Belongs to the ATCase/OTCase family.

Pfam	PF00185; OTCace; 1;
TIGRFAMs	TIGR00670; asp_carb_tr; 1;
PROSITE	PS00097; CARBAMOYLTRANSFERASE; 1;

Pyrimidine biosynthesis, Transferase.

GO:0004070; Molecular function: aspartate carbamoyltransferase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.

Size range:	291-475 amino acids
Related UniRules:	None
Template:	P0A786 (PYRB_ECOLI); P05654 (PYRB_BACSU); Q58976 (PYRB_METJA); Q55338 (PYRB_SULAC): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: MF_00002 (pyrI)
Duplicate:	in SHEHH
Plasmid encoded:	None
Comments:	Possible wrong start in LACLE and SYNY3. Why no pyrB in TREPA?