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| HAMAP annotation rule: MF_02102 |
| Accession | MF_02102 |
| Dates | 7-JUL-2009 (Created) 25-NOV-2009 (Last updated, Version 3) |
| Data class | Protein |
| Predictors | HAMAP; MF_02102; [distribution of match scores in UniProtKB];[seed alignment for MF_02102] |
| Names | PTCase |
| Identifier | PTC |
| Protein name |
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| Gene name | ptcA |
FUNCTION: Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine. Is involved in the degradation pathway of the polyamine agmatine (By similarity).
CATALYTIC ACTIVITY: Carbamoyl phosphate + putrescine = phosphate + N-carbamoylputrescine.
PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from N-carbamoylputrescine (transferase route): step 1/1.
SUBUNIT: Homotrimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the ATCase/OTCase family. PTCase subfamily.
| PROSITE |
PS00097; CARBAMOYLTRANSFERASE; 1; |
| Pfam |
PF00185; OTCace; 1; PF02729; OTCace_N; 1; |
| PRINTS |
PR00100; AOTCASE; 1; PR00102; OTCASE; 1; |
| TIGRFAMs |
TIGR00658; orni_carb_tr; 1; |
GO:0050231; Molecular function: putrescine carbamoyltransferase activity.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.
GO:0033390; Biological process: putrescine biosynthetic process from arginine via N-carbamoylputrescine.
| From: PTC_ENTFA (Q837U7) | ||||||||||
| Key | From | To | Description | Condition | FTGroup | |||||
| REGION | 52 | 56 | Carbamoyl phosphate binding (By similarity) | S-T-R-T-R | ||||||
| REGION | 268 | 271 | Putrescine binding (By similarity) | H-C-L-P | ||||||
| BINDING | 103 | 103 | Carbamoyl phosphate (By similarity) | R | ||||||
| BINDING | 130 | 130 | Carbamoyl phosphate (By similarity) | H | ||||||
| SITE | 27 | 27 | Important for structural integrity (By similarity) | K | ||||||
| SITE | 143 | 143 | Important for structural integrity (By similarity) | E | ||||||
| Size range: | 339-365 amino acids |
| Related UniRules: | MF_01109 (OTC) |
| Template: | Q837U7 (PTC_ENTFA); Q8DW19 (PTC_STRMU): [Recover all] |
| Scope: | Bacteria; Firmicutes Bacteria; Tenericutes |
| Fusion: | Nter: None; Cter: None |
| Duplicate: | None |
| Plasmid encoded: | None |
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