ExPASy Proteomics Server

Accession	MF_01849
Dates	11-JUL-2008 (Created) 25-NOV-2009 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01849; [distribution of match scores in UniProtKB];[seed alignment for MF_01849]

Names

23SrRNA_methyltr_N

Identifier

RLMN

Protein name

RecName: Full=Ribosomal RNA large subunit methyltransferase N; EC=2.1.1.-; AltName: Full=23S rRNA m2A2503 methyltransferase;

Gene name

rlmN

FUNCTION: Specifically methylates position 2 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics (By similarity).

FUNCTION: Specifically methylates position 2 of adenine 2503 in 23S rRNA (By similarity).

COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (Potential).

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the radical SAM superfamily. RlmN family.

Pfam	PF04055; Radical_SAM; 1;
TIGRFAMs	TIGR00048; CHP48; 1;
PIRSF	PIRSF006004; CHP00048; 1;

Cytoplasm, Methyltransferase, rRNA processing, S-adenosyl-L-methionine, Transferase.

4Fe-4S, Iron, Iron-sulfur, Metal-binding.

Antibiotic resistance.

GO:0008757; Molecular function: S-adenosylmethionine-dependent methyltransferase activity.

GO:0005506; Molecular function: iron ion binding.

GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.

From: RLMN_ECOLI (P36979)
Key		From		To		Description		Condition		FTGroup
METAL		125		125		Iron-sulfur (4Fe-4S-S-AdoMet) (Potential)		C		1
METAL		129		129		Iron-sulfur (4Fe-4S-S-AdoMet) (Potential)		C		1
METAL		132		132		Iron-sulfur (4Fe-4S-S-AdoMet) (Potential)		C		1

Size range:	318-431 amino acids
Related UniRules:	MF_01873 (CFR)
Template:	P36979 (RLMN_ECOLI); A5HBL2 (CFR_STAAU): [Recover all]
Scope:	Bacteria Archaea; Crenarchaeota
Fusion:	Nter: None; Cter: None
Duplicate:	in MYXXD, OPITP, PARUW, XANOP
Plasmid encoded:	None
Comments:	Possible wrong starts.