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HAMAP annotation rule: MF_01840

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General rule information

Accession MF_01840
Dates 28-JUL-2005 (Created)
25-NOV-2009 (Last updated, Version 13)
Data class Protein
Predictors HAMAP; MF_01840; [distribution of match scores in UniProtKB];[seed alignment for MF_01840]
Names AcsF


Propagated annotation

Identifier, protein and gene names
Identifier ACSF

case <OG:Chloroplast> or <OC:Cyanobacteria>
Protein name
RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
EC=1.14.13.81;
end case


case not <OG:Chloroplast> and not <OC:Cyanobacteria>
Protein name
RecName: Full=Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
Short=Aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
EC=1.14.13.81;
end case

Gene name acsF
Comments
FUNCTION: Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity).
CATALYTIC ACTIVITY: Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = 13(1)-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP(+) + H(2)O.
CATALYTIC ACTIVITY: 13(1)-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = 13(1)-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP(+) + 2 H(2)O.
CATALYTIC ACTIVITY: 13(1)-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O(2) = divinylprotochlorophyllide + NADP(+) + 2 H(2)O.
COFACTOR: Iron (By similarity).

case <OG:Chloroplast> or <OC:Cyanobacteria>
PATHWAY: Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent).
end case


case not <OG:Chloroplast> and not <OC:Cyanobacteria>
PATHWAY: Porphyrin biosynthesis; bacteriochlorophyll biosynthesis (light-independent).
end case


case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case

SIMILARITY: Belongs to the acsF family.
Cross-references
Pfam PF02915; Rubrerythrin; 1;
TIGRFAMs TIGR02029; AcsF; 1;
Keywords

case not <OG:Chloroplast> and not <OC:Cyanobacteria>
Bacteriochlorophyll biosynthesis.
end case

Chlorophyll biosynthesis, Iron, Metal-binding, NADP, Oxidoreductase, Photosynthesis.
Gene Ontology

case not <OG:Chloroplast> and not <OC:Cyanobacteria>
GO:0030494; Biological process: bacteriochlorophyll biosynthetic process.
end case


case <OG:Chloroplast> or <OC:Cyanobacteria>
GO:0015995; Biological process: chlorophyll biosynthetic process.
end case

GO:0005506; Molecular function: iron ion binding.
GO:0048529; Molecular function: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity.
GO:0015979; Biological process: photosynthesis.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case



Additional information

Size range: 299-390 amino acids
Related UniRules: None
Template: Q8VPB5 (ACSF_RHOGE)
Scope: Bacteria
Bacteria; Cyanobacteria
Bacteria; Alphaproteobacteria
Bacteria; Betaproteobacteria
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in ANASP, THEEB, SYNY3
Plasmid encoded: None

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