ExPASy Proteomics Server

Accession	MF_01808
Dates	17-AUG-2003 (Created) 25-NOV-2009 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_01808; [distribution of match scores in UniProtKB];[seed alignment for MF_01808]

Names

Recomb_XerC

Identifier

XERC

Protein name

RecName: Full=Tyrosine recombinase xerC;

Gene name

xerC

Identifier

XERCL

Protein name

RecName: Full=Probable tyrosine recombinase xerC-like;

FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from xerD binding sites by a short central region, forming the heterotetrameric xerC-xerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex xerC specifically exchanges the top DNA strands (By similarity).

ENZYME REGULATION: FtsK may regulate the catalytic switch between xerC and xerD in the heterotetrameric complex during the two steps of the recombination process (By similarity).

SUBUNIT: Forms a cyclic heterotetrameric complex composed of two molecules of xerC and two molecules of xerD, in which xerC interacts with xerD via its C-terminal region, xerD interacts with xerC via its C-terminal region and so on (By similarity).

FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity).

SUBUNIT: Forms a cyclic heterotetrameric complex composed of two molecules of xerC and two molecules of xerD (By similarity).

FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.

Pfam	PF00589; Phage_integrase; 1; PF02899; Phage_integr_N; 1;
TIGRFAMs	TIGR02224; recomb_XerC; 1;

Cytoplasm, DNA recombination, DNA integration, DNA-binding.

Cell cycle, Cell division, Chromosome partition.

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0006313; Biological process: transposition, DNA-mediated.
GO:0005737; Cellular component: cytoplasm.

From: XERC_ECOLI (P0A8P6)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		148		148		By similarity		R
ACT_SITE		172		172		By similarity		K
ACT_SITE		240		240		By similarity		H
ACT_SITE		243		243		By similarity		R
ACT_SITE		266		266		By similarity		H
ACT_SITE		275		275		O-(3'-phospho-DNA)-tyrosine intermediate (By similarity)		Y

Size range:	250-356 amino acids
Related UniRules:	MF_01807 (XERD (supersedes the current rule)); MF_01817 (XERDL (supersedes the current rule)); MF_01816 (XERS)
Template:	P0A8P6 (XERC_ECOLI); P44818 (XERC_HAEIN); Q51566 (XERC_PSEAE): [Recover all]
Scope:	Archaea Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEAE, RALSO, THETN
Plasmid encoded:	in PSEAE, RALSO, SYNE7
Comments:	XerC is highly related to xerD and it is therefore difficult to discriminate them correctly. Most xerD proteins however contain a [ST]RQ tripeptide that allow to distinguish them from xerC.