ExPASy Proteomics Server

Accession	MF_01678
Dates	21-OCT-2008 (Created) 25-NOV-2009 (Last updated, Version 6)

Data class

Protein

Predictors

HAMAP; MF_01678; [distribution of match scores in UniProtKB];[seed alignment for MF_01678]

Names

Salvage_MtnA

Identifier

MTNA

Protein name

RecName: Full=Methylthioribose-1-phosphate isomerase; Short=MTR-1-P isomerase; Short=M1Pi; EC=5.3.1.23; AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;

Gene name

mtnA

FUNCTION: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity).

CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.

PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.

SUBUNIT: Homodimer.

SIMILARITY: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Pfam	PF01008; IF-2B; 1;
TIGRFAMs	TIGR00524; eIF-2B_rel; 1; TIGR00512; salvage_mtnA; 1; TIGR03328; salvage_mtnB; 1;

Amino-acid biosynthesis, Isomerase, Methionine biosynthesis.

GO:0046523; Molecular function: S-methyl-5-thioribose-1-phosphate isomerase activity.
GO:0019284; Biological process: methionine biosynthetic process from S-adenosylmethionine.

From: MTNA_BACSU (O31662)
Key		From		To		Description		Condition		FTGroup
REGION		51		53		Substrate binding (By similarity)
REGION		250		251		Substrate binding (By similarity)
ACT_SITE		240		240		Proton donor (By similarity)		D
BINDING		94		94		Substrate (By similarity)		R
BINDING		199		199		Substrate (By similarity)		Q
SITE		160		160		Transition state stabilizer (By similarity)		[CS]

Size range:	330-552 amino acids
Related UniRules:	None
Template:	O31662 (MTNA_BACSU)
Scope:	Bacteria
Fusion:	Nter: <Thioesterase>; Cter: None
Duplicate:	in BACAH, BACAN, BACCR, BACCZ, BACHK, BACWK, PETMO, THELT
Plasmid encoded:	in OCHA4, RHIME, SINMW