ExPASy Proteomics Server

Accession	MF_01638
Dates	23-NOV-2006 (Created) 25-NOV-2009 (Last updated, Version 7)

Data class

Protein

Predictors

HAMAP; MF_01638; [distribution of match scores in UniProtKB];[seed alignment for MF_01638]

Names

PdxK

Identifier

PDXK

Protein name

RecName: Full=Pyridoxine kinase; EC=2.7.1.35; AltName: Full=Pyridoxal kinase; AltName: Full=Vitamin B6 kinase; AltName: Full=Pyridoxamine kinase; AltName: Full=PN/PL/PM kinase;

Gene name

pdxK

FUNCTION: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity).

CATALYTIC ACTIVITY: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

COFACTOR: Zinc or magnesium (By similarity).

SIMILARITY: Belongs to the pyridoxine kinase family.

Pfam	PF00294; PfkB; 1;
TIGRFAMs	TIGR00687; pyridox_kin; 1;

ATP-binding, Kinase, Magnesium, Metal-binding, Nucleotide-binding, Transferase, Zinc.

GO:0008270; Molecular function: zinc ion binding.
GO:0005524; Molecular function: ATP binding.
GO:0004340; Molecular function: glucokinase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0006096; Biological process: glycolysis.

From: PDXK_ECOLI (P40191)
Key		From		To		Description		Condition		FTGroup
NP_BIND		195		196		ATP (By similarity)		T-S

Key		From		To		Description		Condition		FTGroup
NP_BIND		220		232		ATP (By similarity)		S-H-S-R-V-K-T-D-L-K-G-T-G

Key		From		To		Description		Condition		FTGroup
NP_BIND		224		236		ATP (By similarity)		A-H-P-R-V-A-T-E-L-K-G-T-G

Key		From		To		Description		Condition		FTGroup
BINDING		23		23		Substrate (By similarity)		S
BINDING		136		136		Substrate (By similarity)		Y
BINDING		233		233		Substrate (By similarity)		D

Size range:	283-296 amino acids
Related UniRules:	None
Template:	P40191 (PDXK_ECOLI)
Scope:	Bacteria; Proteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RALME