Search for
You are here: ExPASy CH  > Databases  > Around UniProtKB  > HAMAP

Home Proteomes Families Documents Downloads Links
HAMAP annotation rule: MF_01633

Send feedback new

General rule information

Accession MF_01633
Dates 3-JUL-2006 (Created)
9-FEB-2010 (Last updated, Version 10)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_01633_B; [distribution of match scores in UniProtKB];[seed alignment for MF_01633_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_01633_A; [distribution of match scores in UniProtKB];[seed alignment for MF_01633_A]
end case

Names QueC


Propagated annotation

Identifier, protein and gene names
Identifier QUEC

case <OC:Bacteria>
Protein name
RecName: Full=7-cyano-7-deazaguanine synthase;
EC=6.3.-.-;
AltName: Full=PreQ(0) synthase;
AltName: Full=7-cyano-7-carbaguanine synthase;
AltName: Full=Queuosine biosynthesis protein queC;
end case


case <OC:Archaea>
Protein name
RecName: Full=7-cyano-7-deazaguanine synthase;
EC=6.3.-.-;
AltName: Full=PreQ(0) synthase;
AltName: Full=7-cyano-7-carbaguanine synthase;
AltName: Full=Archaeosine biosynthesis protein queC;
end case

Gene name queC
Comments
FUNCTION: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity).
CATALYTIC ACTIVITY: 7-carboxy-7-carbaguanine + NH(3) + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H(2)O.

case <FTGroup:1> or <FTGroup:2>
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
end case

PATHWAY: Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.

case <OC:Firmicutes>
SUBUNIT: Homodimer (By similarity).
end case

SIMILARITY: Belongs to the queC family.
Cross-references
Pfam PF06508; ExsB; 1;
TIGRFAMs TIGR00364; ExsB; 1;
PIRSF PIRSF006293; ExsB; 1;
Keywords
ATP-binding, Ligase, Nucleotide-binding.

case <FTGroup:1> or <FTGroup:2>
Metal-binding, Zinc.
end case


case <OC:Bacteria>
Queuosine biosynthesis.
end case

Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0016879; Molecular function: ligase activity, forming carbon-nitrogen bonds.

case <FTGroup:1> or <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case


case <OC:Bacteria>
GO:0008616; Biological process: queuosine biosynthetic process.
end case

Features

case <OC:Bacteria>
From: QUEC_BACSU (O31675)
Key     From     To       Description   Condition   FTGroup
NP_BIND     10     20       ATP (By similarity)      
 
METAL     186     186       Zinc (By similarity)   C   1
METAL     195     195       Zinc (By similarity)   C   1
METAL     198     198       Zinc (By similarity)   C   1
METAL     201     201       Zinc (By similarity)   C   1
end case

case <OC:Archaea>
From: QUEC_METJA (Q58742)
Key     From     To       Description   Condition   FTGroup
NP_BIND     7     17       ATP (By similarity)      
 
METAL     195     195       Zinc (By similarity)   C   2
METAL     206     206       Zinc (By similarity)   C   2
METAL     209     209       Zinc (By similarity)   C   2
METAL     212     212       Zinc (By similarity)   C   2
end case



Additional information


case <OC:Bacteria>
Size range: 196-259 amino acids
end case


case <OC:Archaea>
Size range: 202-241 amino acids
end case

Related UniRules: None
Template: P77756 (QUEC_ECOLI); O31675 (QUEC_BACSU); Q6D820 (QUEC_ERWCT): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: <type-2 glutamine amidotransferase domain>; Cter: None
Duplicate: in COLP3, DESHY, PSEF5, RHILO, RHOP2, SPHAL, SULTO
Plasmid encoded: in HALSA, RHIME, RHISN

View rule in raw text format (no links)



UniProtKB rule member sequences