ExPASy Proteomics Server

Accession	MF_01543
Dates	15-NOV-2005 (Created) 25-NOV-2009 (Last updated, Version 11)

Data class

Protein

Predictors

HAMAP; MF_01543; [distribution of match scores in UniProtKB];[seed alignment for MF_01543]

Names

FTHFS

Identifier

FTHS

Protein name

RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3; AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS;

Gene name

fhs

CATALYTIC ACTIVITY: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.

PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.

SIMILARITY: Belongs to the formate--tetrahydrofolate ligase family.

PROSITE	PS00721; FTHFS_1; 1; PS00722; FTHFS_2; 1;
Pfam	PF01268; FTHFS; 1;

ATP-binding, Ligase, Nucleotide-binding, One-carbon metabolism.

GO:0004329; Molecular function: formate-tetrahydrofolate ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006730; Biological process: one-carbon metabolic process.

From: FTHS_MOOTH (P21164)
Key		From		To		Description		Condition		FTGroup
NP_BIND		68		75		ATP (By similarity)		[TS]-x-x-G-[EIV]-G-K-[TS]

Size range:	505-597 amino acids
Related UniRules:	None
Template:	P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA): [Recover all]
Scope:	Bacteria Archaea; Euryarchaeota
Fusion:	Nter: None; Cter: None
Duplicate:	in DEHE1, DESHY, LACAC, PARDP, RUBXD, SILPO, STRP1, STRP3, STRP6, STRP8, STRPB, STRPC, STRPD, STRPF, STRPG, STRPM, STRSV
Plasmid encoded:	in HALMA