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HAMAP annotation rule: MF_01501

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Accession MF_01501
Dates 4-DEC-2003 (Created)
25-NOV-2009 (Last updated, Version 10)
Data class Protein
Names MtrH



Identifier MTRH
Protein name
RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H;
EC=2.1.1.86;
AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H;
Gene name mtrH
FUNCTION: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of mtrA (By similarity).
CATALYTIC ACTIVITY: 5-methyl-5,6,7,8-tetrahydromethanopterin + 2-mercaptoethanesulfonate = 5,6,7,8-tetrahydromethanopterin + 2-(methylthio)ethanesulfonate.

case <Property:METHANOG>
PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2.
end case

SUBUNIT: The complex is composed of 8 subunits; mtrA, mtrB, mtrC, mtrD, mtrE, mtrF, mtrG and mtrH (By similarity).
SIMILARITY: Belongs to the mtrH family.
Pfam PF02007; MtrH; 1;
TIGRFAMs TIGR01114; mtrH; 1;

case <Property:METHANOG>
end case

GO:0030269; Molecular function: tetrahydromethanopterin S-methyltransferase activity.
GO:0006730; Biological process: one-carbon metabolic process.

case <Property:METHANOG>
GO:0015948; Biological process: methanogenesis.
end case




Size range: 310-322 amino acids
Related UniRules: None
Template: P80187 (MTRH_METTM)
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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