ExPASy Proteomics Server

Accession	MF_01437
Dates	15-MAY-2006 (Created) 25-NOV-2009 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_01437; [distribution of match scores in UniProtKB];[seed alignment for MF_01437]

Names

PgsA

Identifier

PGSA

Protein name

RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; EC=2.7.8.5; AltName: Full=Phosphatidylglycerophosphate synthase; Short=PGP synthase;

Gene name

pgsA

FUNCTION: This protein catalyzes the committed step to the synthesis of the acidic phospholipids (By similarity).

CATALYTIC ACTIVITY: CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).

SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

PROSITE	PS00379; CDP_ALCOHOL_P_TRANSF; 1;
Pfam	PF01066; CDP-OH_P_transf; 1;
TIGRFAMs	TIGR00560; pgsA; 1;

Cell membrane, Cell inner membrane, Membrane, Phospholipid biosynthesis, Transferase, Transmembrane.

GO:0008444; Molecular function: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

From: PGSA_ECOLI (P0ABF8)
Key		From		To		Description		Condition		FTGroup
TOPO_DOM		1		12		Cytoplasmic (Potential)
TRANSMEM		13		37		Potential
TOPO_DOM		38		60		Periplasmic (Potential)
TRANSMEM		61		81		Potential
TOPO_DOM		82		86		Cytoplasmic (Potential)
TRANSMEM		87		107		Potential
TOPO_DOM		108		145		Periplasmic (Potential)
TRANSMEM		146		168		Potential
TOPO_DOM		169		181		Cytoplasmic (Potential)

Size range:	181-190 amino acids
Related UniRules:	None
Template:	P0ABF8 (PGSA_ECOLI)
Scope:	Bacteria; Enterobacteriaceae
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None