ExPASy Proteomics Server

Accession	MF_01405
Dates	8-AUG-2002 (Created) 25-NOV-2009 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_01405; [distribution of match scores in UniProtKB];[seed alignment for MF_01405]

Names

Nucleoside_triphosp

Identifier

RDGB

Protein name

RecName: Full=Nucleoside-triphosphatase rdgB; EC=3.6.1.15; AltName: Full=Nucleoside triphosphate phosphohydrolase; Short=NTPase;

Gene name

rdgB

Identifier

NTPA

Protein name

RecName: Full=Nucleoside-triphosphatase; EC=3.6.1.15; AltName: Full=Nucleoside triphosphate phosphohydrolase; Short=NTPase;

FUNCTION: Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions (By similarity).

FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions (By similarity).

CATALYTIC ACTIVITY: NTP + H(2)O = NDP + phosphate.

COFACTOR: Divalent cations (By similarity).

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the HAM1 NTPase family.

Pfam	PF01725; Ham1p_like; 1;
TIGRFAMs	TIGR00042; Ham1p_like; 1;

Hydrolase.

GO:0017111; Molecular function: nucleoside-triphosphatase activity.

Size range:	184-328 amino acids
Related UniRules:	None
Template:	P52061 (RDGB_ECOLI); Q57679 (NTPA_METJA): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: MF_00564 (rph), <Unknown>; Cter: None
Duplicate:	in BACHD
Plasmid encoded:	None
Comments:	Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1, STRT2