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HAMAP annotation rule: MF_01395

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General rule information

Accession MF_01395
Dates 27-NOV-2008 (Created)
12-NOV-2009 (Last updated, Version 4)
Data class Protein
Predictors HAMAP; MF_01395; [distribution of match scores in UniProtKB];[seed alignment for MF_01395]
Names AcetylCoA_CT_beta


Propagated annotation

Identifier, protein and gene names
Identifier ACCD
Protein name
RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta;
Short=Acetyl-CoA carboxylase carboxyltransferase subunit beta;
Short=ACCase subunit beta;
EC=6.4.1.2;
Gene name accD
Comments
FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA (By similarity).
CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.

case <FTGroup:1>
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
end case

PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) (By similarity).

case <OC:Bacteria>
SUBCELLULAR LOCATION: Cytoplasm (Probable).

else case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast stroma (Probable).
end case

SIMILARITY: Belongs to the accD/PCCB family.
Cross-references
PROSITE PS50980; COA_CT_NTER; 1;
Pfam PF01039; Carboxyl_trans; 1;
PRINTS PR01070; ACCCTRFRASEB; 1;
TIGRFAMs TIGR00515; accD; 1;
Keywords
ATP-binding, Fatty acid biosynthesis, Ligase, Lipid synthesis, Nucleotide-binding.

case <FTGroup:1>
Metal-binding, Zinc, Zinc-finger.
end case


case <OC:Bacteria>
Cytoplasm.
end case

Gene Ontology
GO:0003989; Molecular function: acetyl-CoA carboxylase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.

case <OC:Bacteria>
GO:0005737; Cellular component: cytoplasm.

else case <OG:Chloroplast>
GO:0009570; Cellular component: chloroplast stroma.
end case


case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Features

case not <OC:Mycobacterium>
From: ACCD_ECOLI (P0A9Q5)
Key     From     To       Description   Condition   FTGroup
ZN_FING (Optional)     27     49       C4-type (By similarity)   C-x(1,2)-C-x(12,18)-C-x(1,2)-C  
 
METAL (Optional)     27     27       Zinc (By similarity)   C   1
METAL (Optional)     30     30       Zinc (By similarity)   C   1
METAL (Optional)     46     46       Zinc (By similarity)   C   1
METAL (Optional)     49     49       Zinc (By similarity)   C   1
end case



Additional information


case <OC:Bacteria>
Size range: 254-346 amino acids
end case


case <OG:Chloroplast>
Size range: 288-700 amino acids
end case

Related UniRules: None
Template: P0A9Q5 (ACCD_ECOLI); Q5HF73 (ACCD_STAAC); Q2MI91 (ACCD_SOLLC); P18823 (ACCD_PEA): [Recover all]
Scope: Bacteria
Plastid
Fusion: Nter: None; Cter: MF_00823 (accA)
Duplicate: in EUBE2, LACPJ, LACPL, LYSSC, ROSCS, ROSS1, VIBHB, VIBPA
Plasmid encoded: in EUBE2
Comments: A few Firmicutes encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRASC, FRASN, NATTJ) as do a few Actinobacteria (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations and an occasional fragment of the other form which may or may not be expressed (see rice). The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes. Not all proteins are able to bind the zinc. Mycobacteria do not seem to have this particular protein; they have 6 accD paralogues however.

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UniProtKB rule member sequences