ExPASy Proteomics Server

Accession	MF_01357
Dates	18-NOV-2008 (Created) 30-NOV-2009 (Last updated, Version 5)

Data class

Protein

Predictors

HAMAP; MF_01357; [distribution of match scores in UniProtKB];[seed alignment for MF_01357]

Names

NDH1_NuoC

Identifier

NDHJ

Protein name

RecName: Full=NAD(P)H-quinone oxidoreductase subunit J, chloroplastic; EC=1.6.5.-; AltName: Full=NAD(P)H dehydrogenase, subunit J; AltName: Full=NADH-plastoquinone oxidoreductase subunit J;

Gene name

ndhJ

Identifier

NDHJ

Protein name

RecName: Full=NAD(P)H-quinone oxidoreductase subunit J; EC=1.6.5.-; AltName: Full=NAD(P)H dehydrogenase, subunit J; AltName: Full=NADH-plastoquinone oxidoreductase subunit J; AltName: Full=NDH-1 subunit J; Short=NDH-J;

Gene name

ndhJ

Identifier

NUOC

Protein name

RecName: Full=NADH-quinone oxidoreductase subunit C; EC=1.6.99.5; AltName: Full=NADH dehydrogenase I subunit C; AltName: Full=NDH-1 subunit C;

Gene name

nuoC

FUNCTION: NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient (By similarity).

FUNCTION: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration (By similarity).

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).

CATALYTIC ACTIVITY: NAD(P)H + plastoquinone = NAD(P)(+) + plastoquinol.

CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.

SUBUNIT: NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus (By similarity).

SUBUNIT: NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions (By similarity).

SUBUNIT: NDH-1 is composed of 15 different subunits. Subunits nuoB, C, D, E, F, and G constitute the peripheral sector of the complex (By similarity).

SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits nuoB, C, D, E, F, and G constitute the peripheral sector of the complex (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein; Stromal side (By similarity).

SUBCELLULAR LOCATION: Cellular thylakoid membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).

SIMILARITY: Belongs to the complex I 30 kDa subunit family.

PROSITE	PS00542; COMPLEX1_30K; 1;
Pfam	PF00329; Complex1_30kDa; 1;
TIGRFAMs	TIGR01961; NuoC_fam; 1;

NAD.

NADP, Plastoquinone.

Ubiquinone.

Oxidoreductase, Quinone, Membrane, Transport.

Thylakoid.

Cell membrane, Cell inner membrane.

Cell membrane.

GO:0055114; Biological process: oxidation reduction.
GO:0019684; Biological process: photosynthesis, light reaction.

GO:0016655; Molecular function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor.

GO:0050136; Molecular function: NADH dehydrogenase (quinone) activity.

GO:0009535; Cellular component: chloroplast thylakoid membrane.

GO:0042651; Cellular component: thylakoid membrane.

GO:0005886; Cellular component: plasma membrane.

GO:0005886; Cellular component: plasma membrane.

Size range:	148-309 amino acids
Related UniRules:	MF_01359 (NUOCD (supersedes the current rule)); MF_01397 (NUOCD (supersedes the current rule))
Template:	P33599 (NUOCD_ECOLI); P19125 (NDHJ_SYNY3): [Recover all]
Scope:	Bacteria Plastid
Fusion:	Nter: None; Cter: None
Duplicate:	in RHIE6, RHIME
Plasmid encoded:	in RHIME
Comments:	14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature. In some bacteria this protein is fused with nuoD, see families MF_01359 and MF_01397. In many bacteria there are both the individual and fused versions.