ExPASy Proteomics Server

Accession	MF_01346
Dates	11-APR-2006 (Created) 25-NOV-2009 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_01346; [distribution of match scores in UniProtKB];[seed alignment for MF_01346]

Names

ATP_synth_alpha_bact

Identifier

ATPA

Protein name

RecName: Full=ATP synthase subunit alpha; EC=3.6.3.14; AltName: Full=F-ATPase subunit alpha; AltName: Full=ATP synthase F1 sector subunit alpha;

Protein name

RecName: Full=ATP synthase subunit alpha, chloroplastic; EC=3.6.3.14; AltName: Full=F-ATPase subunit alpha; AltName: Full=ATP synthase F1 sector subunit alpha;

Gene name

atpA

FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity).

CATALYTIC ACTIVITY: ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).

SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a, b, b' and c (By similarity).

SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Peripheral membrane protein (By similarity).

SUBCELLULAR LOCATION: Cellular thylakoid membrane; Peripheral membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (By similarity).

SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).

SIMILARITY: Belongs to the ATPase alpha/beta chains family.

PROSITE	PS00152; ATPASE_ALPHA_BETA; 1;
Pfam	PF00006; ATP-synt_ab; 1; PF00306; ATP-synt_ab_C; 1; PF02874; ATP-synt_ab_N; 1;
TIGRFAMs	TIGR00962; atpA; 1;

ATP synthesis, ATP-binding, CF(1), Hydrolase, Ion transport, Nucleotide-binding, Transport, Hydrogen ion transport, Membrane.

Thylakoid.

Cell membrane, Cell inner membrane.

Cell membrane.

GO:0005524; Molecular function: ATP binding.
GO:0046933; Molecular function: hydrogen ion transporting ATP synthase activity, rotational mechanism.
GO:0042777; Biological process: plasma membrane ATP synthesis coupled proton transport.

GO:0042651; Cellular component: thylakoid membrane.

GO:0005886; Cellular component: plasma membrane.

GO:0009535; Cellular component: chloroplast thylakoid membrane.

From: ATPA_ECOLI (P0ABB0)
Key		From		To		Description		Condition		FTGroup
NP_BIND		169		176		ATP (By similarity)		G-D-[R,K,S]-[Q,A,K,S,G]-[T,I,C,V]-G-K-[T,S,A]
SITE		373		373		Required for activity (By similarity)		S

Size range:	481-670 amino acids
Related UniRules:	None
Template:	P0ABB0 (ATPA_ECOLI)
Scope:	Bacteria Plastid
Fusion:	Nter: None; Cter: <Unknown>
Duplicate:	in BURM7, BURMA, BURMS, BURP0, BURP1, BURP6, BURPS, BURTA, BURXA, BURXL, DINSH, GLUOX, HAHCH, LEGPA, LEGPC, LEGPH, LISIN, LISMF, LISMO, LISW6, MARMS, METCA, MYCPU, NITEC, NITMU, PELCD, PELLD, PELPD, PHOPR, POLNA, PSEA6, PSYIN, RHOBA, RHOFD, RHOS1, SHEFN, SYNAS, VIBHB
Plasmid encoded:	in ACAM1, RHOS1, RHOS4
Comments:	The second copy in some of the Burkholderia is quite a bit longer. There is a 250 residue fusion of unknown function in UREPA and UREP2.