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HAMAP annotation rule: MF_01272

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General rule information

Accession MF_01272
Dates 6-NOV-2006 (Created)
25-NOV-2009 (Last updated, Version 6)
Data class Protein
Predictors HAMAP; MF_01272; [distribution of match scores in UniProtKB];[seed alignment for MF_01272]
Names IsdG


Propagated annotation

Identifier, protein and gene names
Identifier ISDG
Protein name
RecName: Full=Heme-degrading monooxygenase isdG;
EC=1.14.99.3;
AltName: Full=Iron-regulated surface determinant isdG;
AltName: Full=Iron-responsive surface determinant isdG;
AltName: Full=Heme oxygenase;
Gene name isdG
Comments
FUNCTION: Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity).
CATALYTIC ACTIVITY: Heme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase isdG subfamily.
Cross-references
Pfam PF03992; ABM; 1;
Keywords
Cytoplasm, Heme, Iron, Metal-binding, Monooxygenase, Oxidoreductase.
Gene Ontology
GO:0005506; Molecular function: iron ion binding.
GO:0016705; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen.
GO:0020037; Molecular function: heme binding.
GO:0005737; Cellular component: cytoplasm.
Features
From: ISDG_STAAW (Q8NX62)
Key     From     To       Description   Condition   FTGroup
METAL     7     7       Iron (Potential)   N  
METAL     77     77       Iron (heme axial ligand) (Potential)   H  
SITE     67     67       Transition state stabilizer (Potential)      


Additional information

Size range: 104-121 amino acids
Related UniRules: None
Template: Q8NX62 (ISDG_STAAW); Q2FZE2 (ISDG_STAA8); Q2G1J2 (ISDI_STAA8); Q99X56 (ISDI_STAAM); Q81L50 (ISDG_BACAN): [Recover all]
Scope: Bacteria; Firmicutes
Fusion: Nter: None; Cter: None
Duplicate: in STAA3, STAA8, STAAC, STAAM, STAAN, STAAR, STAAS, STAAW
Plasmid encoded: None
Comments: Staphylococcus aureus strains (except STAAB) have two family members; the second one is called isdI.

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