ExPASy Proteomics Server

Accession	MF_01271
Dates	8-NOV-2006 (Created) 25-NOV-2009 (Last updated, Version 8)

Data class

Protein

Predictors

HAMAP; MF_01271; [distribution of match scores in UniProtKB];[seed alignment for MF_01271]

Names

GlcNAc_kinase

Identifier

NAGK

Protein name

RecName: Full=N-acetyl-D-glucosamine kinase; EC=2.7.1.59; AltName: Full=GlcNAc kinase;

Gene name

nagK

FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity).

CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

PATHWAY: Cell wall biogenesis; peptidoglycan recycling.

SIMILARITY: Belongs to the ROK (nagC/xylR) family. NagK subfamily.

PROSITE	PS01125; ROK; 1;
Pfam	PF00480; ROK; 1;

ATP-binding, Carbohydrate metabolism, Kinase, Nucleotide-binding, Transferase.

Metal-binding, Zinc.

GO:0005524; Molecular function: ATP binding.

GO:0008270; Molecular function: zinc ion binding.

GO:0045127; Molecular function: N-acetylglucosamine kinase activity.
GO:0006044; Biological process: N-acetylglucosamine metabolic process.
GO:0009254; Biological process: peptidoglycan turnover.

From: NAGK_ECOLI (P75959)
Key		From		To		Description		Condition		FTGroup
NP_BIND		4		11		ATP (Potential)
NP_BIND		133		140		ATP (Potential)
METAL (Optional)		157		157		Zinc (By similarity)		H		1
METAL (Optional)		177		177		Zinc (By similarity)		C		1
METAL (Optional)		179		179		Zinc (By similarity)		C		1
METAL (Optional)		184		184		Zinc (By similarity)		C		1

Size range:	256-305 amino acids
Related UniRules:	None
Template:	P75959 (NAGK_ECOLI); Q8ZPZ9 (NAGK_SALTY): [Recover all]
Scope:	Bacteria; Gammaproteobacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	NagK sequences from YERPE, YERPA and YERPN (but not YERPS) are shorter, due to a probable natural frameshift in the C-terminus; they are not included in alignment.