ExPASy Proteomics Server

Accession	MF_01234
Dates	24-MAR-2003 (Created) 25-NOV-2009 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_01234; [distribution of match scores in UniProtKB];[seed alignment for MF_01234]

Names

ManNAc_kinase

Identifier

NANK

Protein name

RecName: Full=N-acetylmannosamine kinase; EC=2.7.1.60; AltName: Full=N-acetyl-D-mannosamine kinase; AltName: Full=ManNAc kinase;

Gene name

nanK

FUNCTION: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity).

CATALYTIC ACTIVITY: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.

PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5.

SUBUNIT: Homodimer (By similarity).

SIMILARITY: Belongs to the ROK (nagC/xylR) family. NanK subfamily.

Pfam	PF00480; ROK; 1;
PROSITE	PS01125; ROK; 1;

Carbohydrate metabolism, Transferase, Kinase, ATP-binding, Nucleotide-binding.

Metal-binding, Zinc.

GO:0005524; Molecular function: ATP binding.

GO:0008270; Molecular function: zinc ion binding.

GO:0009384; Molecular function: N-acylmannosamine kinase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
GO:0006051; Biological process: N-acetylmannosamine metabolic process.

From: NANK_ECOLI (P45425)
Key		From		To		Description		Condition		FTGroup
NP_BIND		5		12		ATP (Potential)
NP_BIND		132		139		ATP (Potential)
METAL		156		156		Zinc (By similarity)		H		1
METAL		166		166		Zinc (By similarity)		C		1
METAL		168		168		Zinc (By similarity)		C		1
METAL		173		173		Zinc (By similarity)		C		1

Size range:	287-300 amino acids
Related UniRules:	None
Template:	P45425 (NANK_ECOLI)
Scope:	Bacteria
Fusion:	Nter: MF_01235 (nanE); Cter: None
Duplicate:	in ECOL6
Plasmid encoded:	None