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HAMAP annotation rule: MF_01200

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General rule information

Accession MF_01200
Dates 15-JAN-2002 (Created)
25-NOV-2009 (Last updated, Version 25)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_01200_B; [distribution of match scores in UniProtKB];[seed alignment for MF_01200_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_01200_A; [distribution of match scores in UniProtKB];[seed alignment for MF_01200_A]
end case

Names OMPdecase_type1


Propagated annotation

Identifier, protein and gene names
Identifier PYRF
Protein name
RecName: Full=Orotidine 5'-phosphate decarboxylase;
EC=4.1.1.23;
AltName: Full=OMP decarboxylase;
Short=OMPDCase;
Short=OMPdecase;
Gene name pyrF
Comments
FUNCTION: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity).
CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the OMP decarboxylase family. Type 1 subfamily.
Cross-references
PROSITE PS00156; OMPDECASE; 1;
Pfam PF00215; OMPdecase; 1;
TIGRFAMs TIGR01740; pyrF; 1;
Keywords
Lyase, Decarboxylase, Pyrimidine biosynthesis.
Gene Ontology
GO:0004590; Molecular function: orotidine-5'-phosphate decarboxylase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
Features

case <OC:Bacteria>
From: PYRF_ECOLI (P08244)
Key     From     To       Description   Condition   FTGroup
REGION     71     80       Substrate binding (By similarity)   D-x-K-x-x-D-x-x-x-x  
ACT_SITE     73     73       Proton donor (By similarity)   K  
BINDING     22     22       Substrate (By similarity)   D  
BINDING     44     44       Substrate (By similarity)   K  
BINDING     131     131       Substrate (By similarity)   T  
BINDING     192     192       Substrate (By similarity)   R  
BINDING     201     201       Substrate (By similarity)   Q  
BINDING (Optional)     221     221       Substrate; via amide nitrogen (By similarity)   G  
BINDING     222     222       Substrate (By similarity)   R  
end case

case <OC:Archaea>
From: PYRF_METTH (O26232)
Key     From     To       Description   Condition   FTGroup
REGION     70     79       Substrate binding (By similarity)   D-x-K-x-x-D-x-x-x-x  
REGION     180     190       Substrate binding (By similarity)      
ACT_SITE     72     72       Proton donor (By similarity)   K  
BINDING     20     20       Substrate (By similarity)   D  
BINDING     42     42       Substrate (By similarity)   K  
BINDING     127     127       Substrate (By similarity)   S  
BINDING     202     202       Substrate; via amide nitrogen (By similarity)   G  
BINDING     203     203       Substrate (By similarity)   R  
end case



Additional information


case <OC:Bacteria>
Size range: 224-279 amino acids
end case


case <OC:Archaea>
Size range: 208-244 amino acids
end case

Related UniRules: MF_01215 (PYRF)
Template: P25971 (PYRF_BACSU); P08244 (PYRF_ECOLI); Q59654 (PYRF_PSEAE); P07691 (PYRF_SALTY); O26232 (PYRF_METTH); O74110 (PYRF_THEAC); O58462 (PYRF_PYRHO); Q9WYG7 (PYRF_THEMA): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: MF_01208 (pyrE)
Duplicate: None
Plasmid encoded: None
Comments: Divergent THEMA; sequence not included in alignment and not taken into account in size range

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UniProtKB rule member sequences