ExPASy Proteomics Server

Accession	MF_01123
Dates	24-SEP-2003 (Created) 25-NOV-2009 (Last updated, Version 15)

Data class

Protein

Predictors

HAMAP; MF_01123; [distribution of match scores in UniProtKB];[seed alignment for MF_01123]

Names

Ac_CoA_synth

Identifier

ACSA

Protein name

RecName: Full=Acetyl-coenzyme A synthetase; EC=6.2.1.1; AltName: Full=Acetate--CoA ligase; AltName: Full=Acyl-activating enzyme;

Gene name

acs

Gene name

acsA

FUNCTION: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates cheY, the response regulator involved in flagellar movement and chemotaxis (By similarity).

CATALYTIC ACTIVITY: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

PTM: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme (By similarity).

SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.

Pfam	PF00501; AMP-binding; 1;
PRINTS	PR00154; AMPBINDING; 1;
TIGRFAMs	TIGR01217; ac_ac_CoA_syn; 1;
PROSITE	PS00455; AMP_BINDING; 1;

Acetylation, ATP-binding, Ligase, Nucleotide-binding.

GO:0003987; Molecular function: acetate-CoA ligase activity.

GO:0019427; Biological process: acetyl-CoA biosynthetic process from acetate.
GO:0006935; Biological process: chemotaxis.

From: ACSA_SALTY (Q8ZKF6)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		517		517		By similarity		D
MOD_RES		609		609		N6-acetyllysine (By similarity)		K

Size range:	572-672 amino acids
Related UniRules:	None
Template:	P27550 (ACSA_ECOLI); Q8ZKF6 (ACSA_SALTY): [Recover all]
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in PSEAE, PSEPK, RHIME
Plasmid encoded:	in AGRRH
Comments:	More divergent AcsAs present in BACSU and RHIME were not included in the alignment