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HAMAP annotation rule: MF_01091

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General rule information

Accession MF_01091
Dates 27-NOV-2003 (Created)
25-NOV-2009 (Last updated, Version 19)
Data class Protein
Predictors HAMAP; MF_01091; [distribution of match scores in UniProtKB];[seed alignment for MF_01091]
Names F420_mer


Propagated annotation

Identifier, protein and gene names
Identifier MER
Protein name
RecName: Full=5,10-methylenetetrahydromethanopterin reductase;
EC=1.5.99.11;
AltName: Full=Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase;
AltName: Full=Methylene-H(4)MPT reductase;
Gene name mer
Comments

case <Property:METHANOG>
FUNCTION: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT (By similarity).
end case


case not <Property:METHANOG>
FUNCTION: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT (By similarity).
end case

CATALYTIC ACTIVITY: 5-methyltetrahydromethanopterin + coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420.

case <Property:METHANOG>
PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 1/2.
end case


case <OC:Archaeoglobales>
PATHWAY: Metabolic intermediate metabolism; lactate oxidation.
end case

SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the mer family.
Cross-references
Pfam PF00296; Bac_luciferase; 1;
TIGRFAMs TIGR03555; F420_mer; 1;
Keywords

case <Property:METHANOG>
Cytoplasm, Methanogenesis.
end case

Cytoplasm, One-carbon metabolism, Oxidoreductase.
Gene Ontology
GO:0018537; Molecular function: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity.
GO:0006730; Biological process: one-carbon metabolic process.

case <Property:METHANOG>
GO:0015948; Biological process: methanogenesis.
end case

GO:0005737; Cellular component: cytoplasm.


Additional information

Size range: 321-349 amino acids
Related UniRules: None
Template: Q8TXY4 (MER_METKA); O27784 (MER_METTH); Q50744 (MER_METTM): [Recover all]
Scope: Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences