ExPASy Proteomics Server

Accession	MF_01090
Dates	27-NOV-2003 (Created) 25-NOV-2009 (Last updated, Version 12)

Data class

Protein

Predictors

HAMAP; MF_01090; [distribution of match scores in UniProtKB];[seed alignment for MF_01090]

Names

HMD

Identifier

HMD

Protein name

RecName: Full=5,10-methenyltetrahydromethanopterin hydrogenase; EC=1.12.98.2; AltName: Full=H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase; AltName: Full=N(5),N(10)-methenyltetrahydromethanopterin hydrogenase; AltName: Full=H(2)-dependent methylene-H(4)MPT dehydrogenase;

Gene name

hmd

FUNCTION: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT (By similarity).

CATALYTIC ACTIVITY: H(2) + 5,10-methenyltetrahydromethanopterin = H(+) + 5,10-methylenetetrahydromethanopterin.

PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-methylene-5,6,7,8-tetrahydromethanopterin from 5,10-methenyl-5,6,7,8-tetrahydromethanopterin (hydrogen route): step 1/1.

SIMILARITY: Belongs to the HMD family.

Pfam	PF03201; HMD; 1;

Methanogenesis.

One-carbon metabolism, Oxidoreductase.

GO:0047068; Molecular function: N5,N10-methenyltetrahydromethanopterin hydrogenase activity.
GO:0006730; Biological process: one-carbon metabolic process.

GO:0015948; Biological process: methanogenesis.

Size range:	343-358 amino acids
Related UniRules:	None
Template:	Q02394 (HMD_METKA); P32440 (HMD_METTM); Q50759 (HMD_METTL): [Recover all]
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None