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HAMAP annotation rule: MF_01022

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General rule information

Accession MF_01022
Dates 14-JUN-2002 (Created)
25-NOV-2009 (Last updated, Version 22)
Data class Protein
Predictors HAMAP; MF_01022; [distribution of match scores in UniProtKB];[seed alignment for MF_01022]
Names Bifunc_HisB


Propagated annotation

Identifier, protein and gene names
Identifier HIS7
Protein name
RecName: Full=Histidine biosynthesis bifunctional protein hisB;
RecName: Full=Histidinol-phosphatase;
EC=3.1.3.15;
RecName: Full=Imidazoleglycerol-phosphate dehydratase;
Short=IGPD;
EC=4.2.1.19;
Gene name hisB
Comments
CATALYTIC ACTIVITY: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.
CATALYTIC ACTIVITY: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: In the N-terminal section; belongs to the histidinol-phosphatase family.
SIMILARITY: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
Cross-references
Pfam PF00475; IGPD; 1;
TIGRFAMs TIGR01662; HAD-SF-IIIA; 1;
TIGR01261; hisB_Nterm; 1;
TIGR01656; Histidinol-ppas; 1;
PROSITE PS00954; IGP_DEHYDRATASE_1; 1;
PS00955; IGP_DEHYDRATASE_2; 1;
Keywords
Cytoplasm, Amino-acid biosynthesis, Histidine biosynthesis, Multifunctional enzyme, Lyase, Hydrolase.
Gene Ontology
GO:0004401; Molecular function: histidinol-phosphatase activity.
GO:0004424; Molecular function: imidazoleglycerol-phosphate dehydratase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: HIS7_ECOLI (P06987)
Key     From     To       Description   Condition   FTGroup
REGION     Nter     166       Histidinol-phosphatase      
REGION     167     Cter       Imidazoleglycerol-phosphate dehydratase      


Additional information

Size range: 352-375 amino acids
Related UniRules: MF_00076 (HIS7)
Template: P06987 (HIS7_ECOLI)
Scope: Bacteria; Bacteroidetes
Bacteria; Proteobacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences