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HAMAP annotation rule: MF_01006

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General rule information

Accession MF_01006
Dates 1-MAR-2002 (Created)
25-NOV-2009 (Last updated, Version 34)
Data class Protein
Predictors HAMAP; MF_01006; [distribution of match scores in UniProtKB];[seed alignment for MF_01006]
Names Undec_diphosphatase


Propagated annotation

Identifier, protein and gene names
Identifier UPPP

case <OC:Bacteria>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC=3.6.1.27;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
AltName: Full=Bacitracin resistance protein;
end case


case <OC:Archaea>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC=3.6.1.27;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case

Gene name uppP
Comments

case <OC:Bacteria>
FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity).
end case


case <OC:Archaea>
FUNCTION: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) (By similarity).
end case

CATALYTIC ACTIVITY: Undecaprenyl diphosphate + H(2)O = undecaprenyl phosphate + phosphate.

case <Property:Membrane=1>
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).

else case <Property:Membrane=2>
SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein (By similarity).
end case


case <OC:Bacteria>
MISCELLANEOUS: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
end case

SIMILARITY: Belongs to the uppP family.
Cross-references
Pfam PF02673; BacA; 1;
TIGRFAMs TIGR00753; undec_PP_bacA; 1;
General Transmembrane; -; 5-9; trigger=Yes;
Keywords

case <OC:Bacteria>
Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation.
end case

Hydrolase.

case <Property:Membrane=2>
Cell inner membrane.
end case


case <OC:Bacteria>
Peptidoglycan synthesis.
end case

Cell membrane, Membrane, Transmembrane.
Gene Ontology
GO:0050380; Molecular function: undecaprenyl-diphosphatase activity.

case <OC:Bacteria>
GO:0046677; Biological process: response to antibiotic.
end case

GO:0005886; Cellular component: plasma membrane.


Additional information

Size range: 237-343 amino acids
Related UniRules: None
Template: P60932 (UPPP_ECOLI); P60934 (UPPP_STRPN): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ACIAD, AGRT5, BACAH, BACAN, BACC1, BACCR, BACCZ, BACHD, BACHK, BACLD, BACSK, BURCA, BURCH, BURCM, BURP0, BURP1, BURPS, BURS3, BURTA, BURXL, CHRVO, CLOAB, CLOD6, CORJK, ENTFA, FRAAA, FRASC, MAGSA, OENOB, PSEHT, PSEPF, PSEU5, RHILO, RHORT, SHEON, STRAW, STRCO
Plasmid encoded: in CORST, ENTFA
Comments: UPPP2 from RHILO is shorter but can not easily be extended.

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