ExPASy Proteomics Server

Accession	MF_00823
Dates	6-FEB-2006 (Created) 12-NOV-2009 (Last updated, Version 14)

Data class

Protein

Predictors

HAMAP; MF_00823; [distribution of match scores in UniProtKB];[seed alignment for MF_00823]

Names

AcetylCoA_CT_alpha

Identifier

ACCA

Protein name

RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha; Short=ACCase subunit alpha; EC=6.4.1.2;

Gene name

accA

FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity).

CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate + malonyl-CoA.

PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.

SUBUNIT: Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) (By similarity).

SUBCELLULAR LOCATION: Plastid, chloroplast.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the accA family.

Pfam	PF03255; ACCA; 1; PF01039; Carboxyl_trans; 1; PF00378; ECH; 1;
PRINTS	PR01069; ACCCTRFRASEA; 1;
TIGRFAMs	TIGR00513; accA; 1;
PROSITE	PS50989; COA_CT_CTER; 1;

ATP-binding.

Cytoplasm.

Fatty acid biosynthesis, Ligase, Lipid synthesis, Nucleotide-binding.

GO:0003989; Molecular function: acetyl-CoA carboxylase activity.
GO:0006633; Biological process: fatty acid biosynthetic process.

GO:0009507; Cellular component: chloroplast.

GO:0005737; Cellular component: cytoplasm.

Size range:	255-368 amino acids
Related UniRules:	None
Template:	P0ABD5 (ACCA_ECOLI)
Scope:	Bacteria Plastid
Fusion:	Nter: MF_01395 (accD); Cter: None
Duplicate:	in BACC1
Plasmid encoded:	None
Comments:	A few Firmicutes encode a fusion between accD and accA (CLOTE, EUBR3, FRAAA, FRASC, FRASN, NATTJ) as do a few Actinobacteria (SACEN, SALAI and SALTO). Most plants have 2 forms, the so-called prokaryotic form in their plastids and the eukaryotic form in the cytoplasm. The prokaryotic form is longer than the one found in bacteria. The grass family (Poaceae) have only the eukaryotic form in both locations. The eukaryotic form consists of a single large protein in which are fused all 4 subunits that are separate in prokaryotes.