ExPASy Proteomics Server

Accession	MF_00635
Dates	16-APR-2003 (Created) 25-NOV-2009 (Last updated, Version 10)

Data class

Protein

Predictors

HAMAP; MF_00635; [distribution of match scores in UniProtKB];[seed alignment for MF_00635]

Names

dUTPase_arch

Identifier

DUT

Protein name

RecName: Full=Probable deoxyuridine 5'-triphosphate nucleotidohydrolase; Short=dUTPase; EC=3.6.1.23; AltName: Full=dUTP pyrophosphatase;

Gene name

dut

FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).

CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate.

PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

SIMILARITY: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.

Pfam	PF00692; dUTPase; 1;

Hydrolase, Nucleotide metabolism.

GO:0004170; Molecular function: dUTP diphosphatase activity.
GO:0006220; Biological process: pyrimidine nucleotide metabolic process.

Size range:	150-171 amino acids
Related UniRules:	MF_00146 (DCD)
Template:	Q58502 (DUT_METJA)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None