ExPASy Proteomics Server

Accession	MF_00608
Dates	10-DEC-2002 (Created) 25-NOV-2009 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00608; [distribution of match scores in UniProtKB];[seed alignment for MF_00608]

Names

GTP_cyclohydro_3

Identifier

GCH3

Protein name

RecName: Full=GTP cyclohydrolase III; EC=3.5.4.29;

Gene name

gch3

FUNCTION: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity (By similarity).

CATALYTIC ACTIVITY: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + 2 phosphate.

SIMILARITY: Belongs to the archaeal-type GTP cyclohydrolase family.

Pfam	PF05165; GGDN; 1;
PIRSF	PIRSF009265; GTP_cyclohydro_3; 1;

GTP-binding, Hydrolase, Nucleotide-binding.

GO:0016814; Molecular function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines.

Size range:	221-268 amino acids
Related UniRules:	None
Template:	Q57609 (GCH3_METJA)
Scope:	Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in HALSA
Plasmid encoded:	None