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HAMAP annotation rule: MF_00581

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General rule information

Accession MF_00581
Dates 17-OCT-2002 (Created)
25-NOV-2009 (Last updated, Version 31)
Data class Protein
Predictors HAMAP; MF_00581; [distribution of match scores in UniProtKB];[seed alignment for MF_00581]
Names Arg_succ_synth_type2


Propagated annotation

Identifier, protein and gene names
Identifier ASSY
Protein name
RecName: Full=Argininosuccinate synthase;
EC=6.3.4.5;
AltName: Full=Citrulline--aspartate ligase;
Gene name argG
Comments
CATALYTIC ACTIVITY: ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.
PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
Cross-references
Pfam PF00764; Arginosuc_synth; 1;
TIGRFAMs TIGR00032; argG; 1;
PROSITE PS00564; ARGININOSUCCIN_SYN_1; 1;
PS00565; ARGININOSUCCIN_SYN_2; 1;
Keywords
Cytoplasm, Amino-acid biosynthesis, Arginine biosynthesis, Ligase, ATP-binding, Nucleotide-binding.
Gene Ontology
GO:0004055; Molecular function: argininosuccinate synthase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features
From: ASSY_ECOLI (P0A6E4)
Key     From     To       Description   Condition   FTGroup
NP_BIND     17     25       ATP (By similarity)      
BINDING     43     43       ATP (By similarity)   A  
BINDING     99     99       Citrulline (By similarity)   Y  
BINDING     129     129       ATP; via amide nitrogen (By similarity)   G  
BINDING     131     131       ATP (By similarity)   T  
BINDING     131     131       Aspartate (By similarity)   T  
BINDING     135     135       Citrulline (By similarity)   N  
BINDING     135     135       Aspartate (By similarity)   N  
BINDING     136     136       ATP (By similarity)   D  
BINDING     136     136       Aspartate (By similarity)   D  
BINDING     139     139       Citrulline (By similarity)   R  
BINDING     192     192       Citrulline (By similarity)   S  
BINDING     194     194       ATP (By similarity)   D  
BINDING     201     201       Citrulline (By similarity)   T  
BINDING     203     203       Citrulline (By similarity)   E  
BINDING     280     280       Citrulline (By similarity)   E  


Additional information

Size range: 444-482 amino acids
Related UniRules: MF_00005 (ASSY)
Template: P0A6E4 (ASSY_ECOLI)
Scope: Bacteria
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None
Comments: Argininosuccinate synthase type 1 subfamily in MF_00005.

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