ExPASy Proteomics Server

Accession	MF_00578
Dates	27-AUG-2002 (Created) 25-NOV-2009 (Last updated, Version 17)

Data class

Protein

Predictors

HAMAP; MF_00578; [distribution of match scores in UniProtKB];[seed alignment for MF_00578]

Names

Glu_cys_ligase

Identifier

GSH1

Protein name

RecName: Full=Glutamate--cysteine ligase; EC=6.3.2.2; AltName: Full=Gamma-glutamylcysteine synthetase; AltName: Full=Gamma-ECS; Short=GCS;

Gene name

gshA

CATALYTIC ACTIVITY: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine.

PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.

SIMILARITY: Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.

Pfam	PF04262; Glu_cys_ligase; 1;
TIGRFAMs	TIGR01434; glu_cys_ligase; 1;

ATP-binding, Glutathione biosynthesis, Ligase, Nucleotide-binding.

GO:0004357; Molecular function: glutamate-cysteine ligase activity.
GO:0006750; Biological process: glutathione biosynthetic process.

Size range:	505-535 amino acids
Related UniRules:	MF_00782 (GSHAB)
Template:	P0A6W9 (GSH1_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None