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HAMAP annotation rule: MF_00563

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General rule information

Accession MF_00563
Dates 4-JUN-2002 (Created)
25-NOV-2009 (Last updated, Version 28)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00563_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00563_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00563_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00563_A]
end case

Names AdoHcyase


Propagated annotation

Identifier, protein and gene names
Identifier SAHH
Protein name
RecName: Full=Adenosylhomocysteinase;
EC=3.3.1.1;
AltName: Full=S-adenosyl-L-homocysteine hydrolase;
Short=AdoHcyase;
Gene name ahcY
Comments
CATALYTIC ACTIVITY: S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
COFACTOR: Binds 1 NAD per subunit (By similarity).
PATHWAY: Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the adenosylhomocysteinase family.
Cross-references
Pfam PF05221; AdoHcyase; 1;
PF00670; AdoHcyase_NAD; 1;
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1;
TIGRFAMs TIGR00936; ahcY; 1;
PROSITE PS00738; ADOHCYASE_1; 1;
PS00739; ADOHCYASE_2; 1;
Keywords
Cytoplasm, Hydrolase, NAD, One-carbon metabolism.
Gene Ontology
GO:0004013; Molecular function: adenosylhomocysteinase activity.
GO:0006730; Biological process: one-carbon metabolic process.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: SAHH_RHOCA (P28183)
Key     From     To       Description   Condition   FTGroup
REGION     216     381       NAD binding (By similarity)      
BINDING     54     54       Substrate (By similarity)      
BINDING     128     128       Substrate (By similarity)      
BINDING     189     189       Substrate (By similarity)      
BINDING     219     219       Substrate (By similarity)      
BINDING     223     223       Substrate (By similarity)      
end case

case <OC:Archaea>
From: SAHH_METJA (Q58783)
Key     From     To       Description   Condition   FTGroup
REGION     174     341       NAD binding (By similarity)      
BINDING     123     123       Substrate (By similarity)      
BINDING     148     148       Substrate (By similarity)      
BINDING     178     178       Substrate (By similarity)      
BINDING     182     182       Substrate (By similarity)      
end case



Additional information


case <OC:Bacteria>
Size range: 404-495 amino acids
end case


case <OC:Archaea>
Size range: 405-437 amino acids
end case

Related UniRules: None
Template: P10760 (SAHH_RAT); P28183 (SAHH_RHOCA); Q58783 (SAHH_METJA): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None

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UniProtKB rule member sequences