ExPASy Proteomics Server

Accession	MF_00440
Dates	22-AUG-2001 (Created) 25-NOV-2009 (Last updated, Version 28)

Data class

Protein

Predictors

HAMAP; MF_00440; [distribution of match scores in UniProtKB];[seed alignment for MF_00440]

Names

NrdR

Identifier

NRDR

Protein name

RecName: Full=Transcriptional repressor nrdR;

Gene name

nrdR

FUNCTION: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes (By similarity).

COFACTOR: Binds 1 zinc ion (By similarity).

SIMILARITY: Belongs to the nrdR family.

SIMILARITY: Contains 1 ATP-cone domain.

Pfam	PF03477; ATP-cone; 1;
TIGRFAMs	TIGR00244; RNR_NrdR-like; 1;
PROSITE	PS51161; ATP_CONE; 1; trigger=PRU00492;

ATP-binding, DNA-binding, Nucleotide-binding, Repressor, Transcription, Transcription regulation.

Metal-binding, Zinc, Zinc-finger.

GO:0016564; Molecular function: transcription repressor activity.

GO:0008270; Molecular function: zinc ion binding.

From: NRDR_STRCO (O69980)
Key		From		To		Description		Condition		FTGroup
ZN_FING		3		34		By similarity		C-x(2)-C-x(22,24)-C-x(1,2)-C		1

Size range:	146-200 amino acids
Related UniRules:	None
Template:	O69980 (NRDR_STRCO)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in MAGSA
Plasmid encoded:	in NATPD
Comments:	The ATP cone domain can be modelled using the structures for nrdA from E.coli, see AC P00452 and PDB cross-links therein. See also: [1] PubMed=15949864 Rodionov D.A., Gelfand M.S.; "Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling."; Trends Genet. 21:385-389(2005). [2] PubMed=16950922; DOI=10.1128/JB.00903-06; Grinberg I., Shteinberg T., Gorovitz B., Aharonowitz Y., Cohen G., Borovok I.; "The Streptomyces NrdR transcriptional regulator is a Zn ribbon/ATP cone protein that binds to the promoter regions of class Ia and class II ribonucleotide reductase operons."; J. Bacteriol. 188:7635-7644(2006).