ExPASy Proteomics Server

Accession	MF_00423
Dates	8-AUG-2001 (Created) 25-NOV-2009 (Last updated, Version 22)

Data class

Protein

Predictors

HAMAP; MF_00423; [distribution of match scores in UniProtKB];[seed alignment for MF_00423]

Names

SelA

Identifier

SELA

Protein name

RecName: Full=L-seryl-tRNA(Sec) selenium transferase; EC=2.9.1.1; AltName: Full=Selenocysteine synthase; Short=Sec synthase; AltName: Full=Selenocysteinyl-tRNA(Sec) synthase;

Gene name

selA

FUNCTION: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity).

CATALYTIC ACTIVITY: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate.

COFACTOR: Pyridoxal phosphate (By similarity).

PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.

SUBUNIT: Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the selA family.

Pfam	PF03841; SelA; 1;
TIGRFAMs	TIGR00474; selA; 1;

Cytoplasm, Transferase, Pyridoxal phosphate, Selenium, Protein biosynthesis.

GO:0004125; Molecular function: L-seryl-tRNASec selenium transferase activity.
GO:0001514; Biological process: selenocysteine incorporation.
GO:0005737; Cellular component: cytoplasm.

From: SELA_ECOLI (P0A821)
Key		From		To		Description		Condition		FTGroup
MOD_RES		295		295		N6-(pyridoxal phosphate)lysine (By similarity)		K

Size range:	386-475 amino acids
Related UniRules:	None
Template:	P0A821 (SELA_ECOLI); P56372 (SELA_DESBA); O33277 (SELA_MOOTH): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	in RHIME
Comments:	A divergent RHILO gene exists (mlr3804)