ExPASy Proteomics Server

Accession	MF_00418
Dates	19-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 31)

Data class

Protein

Predictors

HAMAP; MF_00418; [distribution of match scores in UniProtKB];[seed alignment for MF_00418]

Names

DapA

Identifier

DAPA

Protein name

RecName: Full=Dihydrodipicolinate synthase; Short=DHDPS; EC=4.2.1.52;

Gene name

dapA

CATALYTIC ACTIVITY: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O.

PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.

SUBUNIT: Homotetramer (By similarity).

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the DHDPS family.

Pfam	PF00701; DHDPS; 1;
PRINTS	PR00146; DHPICSNTHASE; 1;
TIGRFAMs	TIGR00674; dapA; 1;
PROSITE	PS00665; DHDPS_1; 1; PS00666; DHDPS_2; 1;

Cytoplasm, Amino-acid biosynthesis, Diaminopimelate biosynthesis, Lyase, Lysine biosynthesis, Schiff base.

GO:0008840; Molecular function: dihydrodipicolinate synthase activity.
GO:0019877; Biological process: diaminopimelate biosynthetic process.
GO:0009085; Biological process: lysine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: DAPA_ECOLI (P0A6L2)
Key		From		To		Description		Condition		FTGroup
REGION (Optional)		48		49		Pyruvate binding (By similarity)		[AGSTNPM]-[ANPSTG]		1
ACT_SITE		161		161		Schiff-base intermediate with substrate (By similarity)		K
BINDING (Optional)		106		106		Pyruvate (By similarity)		Y		1
SITE		133		133		Involved in proton transfer during cleavage (By similarity)		Y

Size range:	283-311 amino acids
Related UniRules:	MF_01237 (NANA (supersedes the current rule)); MF_00694 (KDGD)
Template:	P0A6L2 (DAPA_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	in BACHD, CLOAB, STRCO
Plasmid encoded:	in RHIME