ExPASy Proteomics Server

Accession	MF_00412
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 33)

Data class

Protein

Predictors

HAMAP; MF_00412; [distribution of match scores in UniProtKB];[seed alignment for MF_00412]

Names

ProA

Identifier

PROA

Protein name

RecName: Full=Gamma-glutamyl phosphate reductase; Short=GPR; EC=1.2.1.41; AltName: Full=Glutamate-5-semialdehyde dehydrogenase; AltName: Full=Glutamyl-gamma-semialdehyde dehydrogenase; Short=GSA dehydrogenase;

Gene name

proA

FUNCTION: Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity).

CATALYTIC ACTIVITY: L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH.

PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.

SUBCELLULAR LOCATION: Cytoplasm (By similarity).

SIMILARITY: Belongs to the gamma-glutamyl phosphate reductase family.

Pfam	PF00171; Aldedh; 1;
PIRSF	PIRSF000151; GPR; 1;
TIGRFAMs	TIGR00407; proA; 1;
PROSITE	PS01223; PROA; 1;

Cytoplasm, Oxidoreductase, Amino-acid biosynthesis, Proline biosynthesis, NADP.

GO:0004350; Molecular function: glutamate-5-semialdehyde dehydrogenase activity.
GO:0006561; Biological process: proline biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Size range:	409-455 amino acids
Related UniRules:	None
Template:	P07004 (PROA_ECOLI)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Divergent, proA-like protein in SYNY3