ExPASy Proteomics Server

Accession	MF_00409
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 19)

Data class

Protein

Predictors

HAMAP; MF_00409; [distribution of match scores in UniProtKB];[seed alignment for MF_00409]

Names

LpxK

Identifier

LPXK

Protein name

RecName: Full=Tetraacyldisaccharide 4'-kinase; EC=2.7.1.130; AltName: Full=Lipid A 4'-kinase;

Gene name

lpxK

FUNCTION: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity).

CATALYTIC ACTIVITY: ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate).

PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.

SIMILARITY: Belongs to the lpxK family.

Pfam	PF02606; LpxK; 1;
TIGRFAMs	TIGR00682; lpxK; 1;

Transferase, Kinase, Lipid A biosynthesis, Lipid synthesis, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0009029; Molecular function: tetraacyldisaccharide 4'-kinase activity.
GO:0009245; Biological process: lipid A biosynthetic process.

From: LPXK_ECOLI (P27300)
Key		From		To		Description		Condition		FTGroup
NP_BIND		55		62		ATP (Potential)		x(2)-G-G-x-G-K-T

Size range:	305-385 amino acids
Related UniRules:	None
Template:	P27300 (LPXK_ECOLI)
Scope:	Bacteria
Fusion:	Nter: None; Cter: MF_01187 (Ynnn)
Duplicate:	None
Plasmid encoded:	None