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HAMAP annotation rule: MF_00403

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General rule information

Accession MF_00403
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 34)
Data class Protein

case <OC:Bacteria> or <OG:Chloroplast>
Predictors HAMAP; MF_00403_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00403_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00403_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00403_A]
end case

Names Ribosomal_S12


Propagated annotation

Identifier, protein and gene names

case <OC:Bacteria> and not <OC:Cyanobacteria>
Identifier RS12
Protein name
RecName: Full=30S ribosomal protein S12;
Gene name rpsL
end case


case <OC:Cyanobacteria>
Identifier RS12
Protein name
RecName: Full=30S ribosomal protein S12;
Gene name rpsL, rps12
end case


case <OC:Archaea>
Identifier RS12
Protein name
RecName: Full=30S ribosomal protein S12P;
Gene name rps12p
end case


case <OG:Chloroplast>
Identifier RR12
Protein name
RecName: Full=30S ribosomal protein S12, chloroplastic;
Gene name rps12
end case

Comments

case <OC:Bacteria>
FUNCTION: With S4 and S5 plays an important role in translational accuracy (By similarity).
FUNCTION: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity).
SUBUNIT: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex (By similarity).
end case


case <OC:Archaea>
FUNCTION: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity).
SUBUNIT: Part of the 30S ribosomal subunit (By similarity).
end case


case <OG:Chloroplast>
FUNCTION: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits (By similarity).
SUBUNIT: Part of the 30S ribosomal subunit (By similarity).
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case

SIMILARITY: Belongs to the ribosomal protein S12P family.
Cross-references
Pfam PF00164; Ribosomal_S12; 1;
PRINTS PR01034; RIBOSOMALS12; 1;
TIGRFAMs TIGR00981; rpsL_bact; 1;
TIGR00982; S23_S12_E_A; 1;
PROSITE PS00055; RIBOSOMAL_S12; 1;
Keywords

case <FT:2>
Acetylation.
end case

Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding.

case <OC:Bacteria>
tRNA-binding.
end case

Gene Ontology
GO:0019843; Molecular function: rRNA binding.

case <OC:Bacteria>
GO:0000049; Molecular function: tRNA binding.
end case

GO:0006412; Biological process: translation.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case

Features

case <OC:Bacteria>
From: RS12_ECOLI (P0A7S3)
Key     From     To       Description   Condition   FTGroup
MOD_RES     89     89       3-methylthioaspartic acid (By similarity)   D  
end case

case <OC:Escherichia> or <OC:Shigella>
Key     From     To       Description   Condition   FTGroup
MOD_RES     108     108       N6-acetyllysine (By similarity)   K  
end case



Additional information


case <OC:Bacteria>
Size range: 117-144 amino acids
end case


case <OC:Archaea>
Size range: 141-151 amino acids
end case

Related UniRules: None
Template: P21472 (RS12_BACSU); P0A7S3 (RS12_ECOLI); Q6N4T2 (RS12_RHOPA); Q5SHN3 (RS12_THET8); P14149 (RR12_CHLRE): [Recover all]
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: None
Duplicate: in AQUAE, BARBK, RHOS1
Plasmid encoded: None

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UniProtKB rule member sequences