ExPASy Proteomics Server

Accession	MF_00384
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 24)

Data class

Protein

Predictors

HAMAP; MF_00384; [distribution of match scores in UniProtKB];[seed alignment for MF_00384]

Names

Homoser_kinase

Identifier

KHSE

Protein name

RecName: Full=Homoserine kinase; Short=HSK; Short=HK; EC=2.7.1.39;

Gene name

thrB

CATALYTIC ACTIVITY: ATP + L-homoserine = ADP + O-phospho-L-homoserine.

PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.

SUBCELLULAR LOCATION: Cytoplasm (Potential).

SIMILARITY: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Pfam	PF08544; GHMP_kinases_C; 1; PF00288; GHMP_kinases_N; 1;
PIRSF	PIRSF000676; Homoser_kin; 1;
PRINTS	PR00958; HOMSERKINASE; 1;
TIGRFAMs	TIGR00191; thrB; 1;
PROSITE	PS00627; GHMP_KINASES_ATP; 1;

Cytoplasm, Amino-acid biosynthesis, Threonine biosynthesis, Transferase, Kinase, ATP-binding, Nucleotide-binding.

GO:0005524; Molecular function: ATP binding.
GO:0004413; Molecular function: homoserine kinase activity.
GO:0009088; Biological process: threonine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

From: KHSE_ECOLI (P00547)
Key		From		To		Description		Condition		FTGroup
NP_BIND		91		101		ATP (Potential)		[APKR]-x(3)-G-[LFM]-G-[GS]-S-[GSA]-[STAC]

Size range:	281-324 amino acids
Related UniRules:	MF_00217 (KIME)
Template:	Q58504 (KHSE_METJA)
Scope:	Bacteria Archaea
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Some other species have a non-classical-type thrB