ExPASy Proteomics Server

Accession	MF_00347
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 21)

Data class

Protein

Predictors

HAMAP; MF_00347; [distribution of match scores in UniProtKB];[seed alignment for MF_00347]

Names

Polyphosphate_kinase

Identifier

PPK

Protein name

RecName: Full=Polyphosphate kinase; EC=2.7.4.1; AltName: Full=Polyphosphoric acid kinase; AltName: Full=ATP-polyphosphate phosphotransferase;

Gene name

ppk

FUNCTION: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity).

CATALYTIC ACTIVITY: ATP + (phosphate)(n) = ADP + (phosphate)(n+1).

PTM: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to histidine residues through a N-P bond (By similarity).

SIMILARITY: Belongs to the polyphosphate kinase family.

SIMILARITY: Contains 1 PLD phosphodiesterase domain.

Pfam	PF02503; PP_kinase; 1;
PROSITE	PS50035; PLD; 0-1; trigger=PRU00153;

ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, Transferase.

GO:0008976; Molecular function: polyphosphate kinase activity.
GO:0006799; Biological process: polyphosphate biosynthetic process.

From: PPK_ECOLI (P0A7B1)
Key		From		To		Description		Condition		FTGroup
ACT_SITE		435		435		Phosphohistidine intermediate (By similarity)		H
ACT_SITE		454		454		Phosphohistidine intermediate (By similarity)		H

Size range:	675-746 amino acids
Related UniRules:	None
Template:	P0A7B1 (PPK_ECOLI); Q07411 (PPK_KLEPN); Q9JXS9 (PPK_NEIMB): [Recover all]
Scope:	Bacteria
Fusion:	Nter: None; Cter: None
Duplicate:	None
Plasmid encoded:	None