ExPASy Proteomics Server

Accession	MF_00298
Dates	1-JUN-2001 (Created) 25-NOV-2009 (Last updated, Version 20)

Data class

Protein

Predictors

HAMAP; MF_00298; [distribution of match scores in UniProtKB];[seed alignment for MF_00298]

Names

Nudix_RppH

Identifier

RPPH

Protein name

RecName: Full=RNA pyrophosphohydrolase; EC=3.6.1.-; AltName: Full=(Di)nucleoside polyphosphate hydrolase;

Gene name

rppH, nudH

FUNCTION: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity).

COFACTOR: Divalent ions (By similarity).

SIMILARITY: Belongs to the Nudix hydrolase family. RppH subfamily.

Pfam	PF00293; NUDIX; 1;
PRINTS	PR00502; NUDIXFAMILY; 1;
PROSITE	PS51462; NUDIX; 1; trigger=PRU00794; PS00893; NUDIX_BOX; 1;

Hydrolase.

GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.

From: RPPH_ECOLI (P0A776)
Key		From		To		Description		Condition		FTGroup
MOTIF		38		59		Nudix box

Size range:	155-238 amino acids
Related UniRules:	None
Template:	P0A776 (RPPH_ECOLI); Q9ZDT9 (RPPH_RICPR): [Recover all]
Scope:	Bacteria
Fusion:	Nter: <Unknown>; Cter: None
Duplicate:	None
Plasmid encoded:	None
Comments:	Unknown N-terminal domain in COXBU