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HAMAP annotation rule: MF_00282

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General rule information

Accession MF_00282
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 27)
Data class Protein
Predictors HAMAP; MF_00282; [distribution of match scores in UniProtKB];[seed alignment for MF_00282]
Names Phe_tRNA_synth_alpha2


Propagated annotation

Identifier, protein and gene names
Identifier SYFA
Protein name
RecName: Full=Phenylalanyl-tRNA synthetase alpha chain;
EC=6.1.1.20;
AltName: Full=Phenylalanine--tRNA ligase alpha chain;
Short=PheRS;
Gene name pheS
Comments
CATALYTIC ACTIVITY: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
COFACTOR: Binds 2 magnesium ions per tetramer (By similarity).
SUBUNIT: Tetramer of two alpha and two beta chains (By similarity).

case <OG:Chloroplast>
SUBCELLULAR LOCATION: Plastid, chloroplast.
end case


case not <OG:Chloroplast>
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
end case

SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 2 subfamily.
Cross-references
Pfam PF01409; tRNA-synt_2d; 1;
TIGRFAMs TIGR00468; pheS; 1;
PROSITE PS50862; AA_TRNA_LIGASE_II; 1;
Keywords

case not <OG:Chloroplast>
Cytoplasm.
end case

Aminoacyl-tRNA synthetase, ATP-binding, Ligase, Magnesium, Metal-binding, Nucleotide-binding, Protein biosynthesis.
Gene Ontology
GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0004826; Molecular function: phenylalanine-tRNA ligase activity.
GO:0006432; Biological process: phenylalanyl-tRNA aminoacylation.

case <OG:Chloroplast>
GO:0009507; Cellular component: chloroplast.
end case


case not <OG:Chloroplast>
GO:0005737; Cellular component: cytoplasm.
end case



Additional information

Size range: 465-553 amino acids
Related UniRules: MF_00281 (SYFA)
Template: P27002 (SYFB_THETH); O26837 (SYFA_METTH): [Recover all]
Scope: Bacteria
Archaea
Plastid
Fusion: Nter: None; Cter: None
Duplicate: None
Plasmid encoded: None
Comments: Generally found in archaea, but also present in BORBU and TREPA. Possible wrong starts various sequences

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UniProtKB rule member sequences