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HAMAP annotation rule: MF_00224

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General rule information

Accession MF_00224
Dates 1-JUN-2001 (Created)
25-NOV-2009 (Last updated, Version 29)
Data class Protein

case <OC:Bacteria>
Predictors HAMAP; MF_00224_B; [distribution of match scores in UniProtKB];[seed alignment for MF_00224_B]
end case


case <OC:Archaea>
Predictors HAMAP; MF_00224_A; [distribution of match scores in UniProtKB];[seed alignment for MF_00224_A]
end case

Names DHO_dh_type1


Propagated annotation

Identifier, protein and gene names
Identifier PYRD
Protein name
RecName: Full=Dihydroorotate dehydrogenase;
EC=1.3.3.1;
AltName: Full=Dihydroorotate oxidase;
AltName: Full=DHOdehase;
Short=DHODase;
Short=DHOD;
Gene name pyrD
Comments
CATALYTIC ACTIVITY: (S)-dihydroorotate + O(2) = orotate + H(2)O(2).
COFACTOR: Binds 1 FMN per subunit (By similarity).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (O2 route): step 1/1.
SUBUNIT: Heterotetramer of 2 pyrK and 2 pyrD subunits (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
Cross-references
Pfam PF01180; DHO_dh; 1;
PIRSF PIRSF000164; DHO_oxidase; 1;
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1;
PROSITE PS00911; DHODEHASE_1; 1;
PS00912; DHODEHASE_2; 1;
Keywords
Cytoplasm, Pyrimidine biosynthesis, Oxidoreductase, Flavoprotein, FMN.
Gene Ontology
GO:0004158; Molecular function: dihydroorotate oxidase activity.
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Features

case <OC:Bacteria>
From: PYRD_BACSU (P25996)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     128     128       Nucleophile (By similarity)   C  
end case

case <OC:Archaea>
From: PYRD_ARCFU (O29513)
Key     From     To       Description   Condition   FTGroup
ACT_SITE     128     128       Nucleophile (By similarity)   [SC]  
end case



Additional information


case <OC:Bacteria>
Size range: 270-313 amino acids
end case


case <OC:Archaea>
Size range: 290-309 amino acids
end case

Related UniRules: MF_00225 (PYRD)
Template: P25996 (PYRD_BACSU); Q53ZE5 (PYRDA_LACLC): [Recover all]
Scope: Bacteria
Archaea
Fusion: Nter: None; Cter: None
Duplicate: in ENTFA, LACLA, LACLM
Plasmid encoded: None

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UniProtKB rule member sequences